To give you an idea just how much phone traffic was being routed through that building, they had a major power failure at that site and it took down most of the north eastern US's phone network:
On September 17, 1991, management failure, power equipment failure, and human error combined to disable AT&T's central office switch at 33 Thomas. More than five million calls were blocked, and the Federal Aviation Administration private lines were also interrupted, disrupting air traffic control to 398 airports serving most of the northeastern United States.
I was curious and checked out the wikipedia page on CYP2D6 and it says CDB is also a strong CYP2D6 inhibitor but I don't have a formal background in this stuff.
The CYP[XYX] enzymes process just about everything that isn't a starch, a protein, or a lipid. So whenever you eat anything, something in that food is going to interact with a CYP enzyme somehow -- even the plainest white bread contains acrylamide, which is metabolized by CYP2E1 and others.
Point is, there's a huge laundry list of drugs and dietary chemicals that inhibit or induce CYP enzymes. That Wikipedia list is far from complete.
...If there's a phamacological interest in CYP2D6 inhibitors, whatever goldenseal constituent is responsible (and it's assuredly a small molecule that is metabolized by CYP2D6, because that's how these things work,) can be isolated and improved upon. This is relatively simple and predictable in comparison with making new drug analogs and estimating their effect.
So if I were OP, I'd focus more on CYP2D6 inhibition as the surer thing.
be an npc. drive a boring car—who gives a fuck? have a boring job. do nothing after work. why do you have to do something after work? do something because you feel like doing it, not because you feel like you have to.
There will inevitably be some people who dismiss this story as a dishonest marketing trick by OpenAI to make their models sound terrifyingly effective. I found 81 instances of the term “marketing” in the Hacker News discussion of the incident.
But a marketing stunt isn't the only possibility. Until this is all verified by investigators or 3rd party experts we can't rule out an act of corporate espionage either. Extraordinary claims require extraordinary evidence.
https://theintercept.com/2016/11/16/the-nsas-spy-hub-in-new-...
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